The XVI Resistive-Plate-Chamber Workshop, held at CERN from the 26th to the 30th of September 2022, continues a long tradition of scientific meetings on this detection technique, which is largely employed in elementary particle and astro-particle physics experiments. The focus of the workshop is on the performance and possible upgrade scenarios of large RPC systems as well as applications outside the particle physics context. This edition aims to acknowledge the fundamental role of CERN in detector technologies for the worldwide community of particle physicists. The most challenging questions in physics are now related to the search for dark matter, long lived particles, astro-particle physics, and physics at high energy colliders. This calls for new challenges in detector layout, front end electronics, materials, gas mixtures, aging and new ideas for improving detector performances in the domain of rate capability and space-time resolution. In the seminar the key points coming out from the workshop will be summarised.