In July 2025, LHC injected for the first time Oxygen and Neon. Motivated by physics questions of the heavy-ion and cosmic-ray community, Oxygen-Oxygen, Neon-Neon and proton-Oxygen collisions took place. The seminar reviews the first results of ALICE, ATLAS, CMS and LHCb. The data are used to study the emergence of collective phenomena and the presence of parton energy loss in small collision systems as well as to study particle production important for understanding processes happening when cosmic rays hit the earth’s atmosphere.