Low-energy searches for rare processes and fundamental symmetry violations provide a promising avenue for discovering hints of new physics. Fully leveraging experiments which utilize nuclei as laboratories requires input from non-perturbative QCD calculations, namely, lattice QCD. Meanwhile, lattice QCD itself has reached a level of maturity to produce direct Standard Model predictions of certain quantities which can match or rival experimental precision, allowing potential discrepancies to be observed. In this talk, I will present several ways in which lattice QCD can interplay with experimental low-energy searches for new physics. I will discuss the state-of-the-art of lattice calculations of single- and two-nucleon observable, in particular focusing on those relevant for neutrino scattering, direct dark matter detection, and neutrinoless double beta decay experiments.